Stem Cell Research News ($)
Stem Cell Business News ($)
The Stem Cell Trekker
Subscription Page
It's  

 

 

13th Edition Guide to Stem Cell Research Companies

Complete listing of global companies performing stem cell research... PLUS stem cell research suppliers AND for-profit cord blood banks! 214 companies in all ... Soon  available in a paperback edition.

Click for more information
Stem Cell Primer

27 pages ... PDF ... Everything you need to know about stem cells and stem cell science.

Only $5.00 (limited time offer)

Click here to order ...

How can I access archived ($) content? 

Start a subscription to Stem Cell Research News at the low individual annual rate to access ALL archived content on this Web site. All articles are posted for free access for seven days. Afterward, articles are archived and require a subscription. 

Click for more information

 
Bone Marrow Stem Cell Release Regulated By Brain’s Biological Clock
Wednesday, February 06, 2008 - Stem Cell Research Daily

The release of blood stem cells from bone marrow is regulated by the brain through the cyclical human biological clock, via adrenergic signals transmitted by the sympathetic nervous system, Mount Sinai researchers have discovered.

Published online on February 6 on the Web site of the journal Nature, the study points out that the harvest of stem cells for transplantation may be improved by timing it at the peak of their release.

The study describes the mechanisms at the molecular levels in which signals from the biological clock in the brain are sent via the sympathetic, or “fight or flight,” branch of the nervous system, directly to bone marrow stem cell niches.

Researchers, using mice as a model, were able to show the rhythmic release and peak of stem cells in circulation during the mouse’s resting period, and that changes in the light cycle or an experimental “jet lag” altered the release patterns.

This is the first time a study has demonstrated that the brain regulates a stem cell niche.

“We don’t know why stem cells circulate in the blood but the maximal release of stem cells in the circulation occurs when the animal is resting. This argues for a role in regeneration,” said Paul S. Frenette, M.D., professor in the department of medicine at Mount Sinai School of Medicine. “More practically, the rhythmic oscillations of circulating stem cells suggest that harvest could be optimized by simply timing the collection of stem cells at the peak of release.”

The vast majority of bone marrow transplantation procedures are currently done using stem cells harvested in the peripheral blood.

The current harvesting procedure, however, may not be adequate in some patients, particularly in those that have received prior treatments for cancer.

“What is really amazing to us is that the brain, through the autonomous branch of the nervous system, directly controls stem cells in their microenvironment,” Frenette said. “An important implication in today’s busy world is that changes in normal biological rhythms, for example by working night shifts or a jet lag, could affect the number of stem cells harvested from donors,”

Contact: 212-659-9693, paul.frenette@mssm.edu


Scroll down to see related articles below. 
 



Related Articles :

E-mail this stem cell article to a friend - Print this stem cell article
Articles can be e-mailed to a friend or you can get a printable version of the article.

 
Search Stem Cell Articles :
Enter key word(s)

 
 
 

 



 
 



 

Copyright © 2003 -  2014 by DataTrends Publications, Inc. All rights reserved.